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3671 matches
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organism
protein
1)
Homo sapiens
CD1A - T-cell
surface
glycoprotein CD1a;
Antigen
-presenting
protein
that binds self and non-self lipid and glycolipid
antigens
and presents them to T-cell receptors on natural killer T-cells.
[a.k.a. BAG35786.1, AAA51932.1, Q9Y5M5]
2)
Homo sapiens
CD1B - T-cell
surface
glycoprotein CD1b;
Antigen
-presenting
protein
that binds self and non-self lipid and glycolipid
antigens
and presents them to T-cell receptors on natural killer T-cells.
[a.k.a. 5L2J, XP_011508421.1, NM_001764.3]
3)
Homo sapiens
CD1C - T-cell
surface
glycoprotein CD1c;
Antigen
-presenting
protein
that binds self and non-self lipid and glycolipid
antigens
and presents them to T-cell receptors on natural killer T-cells.
[a.k.a. CD1C-202, 911, CAG33361.1]
4)
Homo sapiens
CD79A - B-cell
antigen
receptor complex-associated
protein
alpha chain; Required in cooperation with CD79B for initiation of the signal transduction cascade activated by binding of
antigen
to the B- cell
antigen
receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and
antigen
presentation. Also required for BCR
surface
expression and for efficient differentiation of pro- and pre-B-cells. Stimulates SYK autophosphorylation and activation. Binds to BLNK, bringing BLNK into proximity with SYK and allowing SYK to phosphorylate BLNK. Also interacts wit [...]
[a.k.a. R-HSA-983705, MB1, S46706]
5)
Homo sapiens
LIMS2 - LIM and senescent cell
antigen
-like-containing domain
protein
2; Adapter
protein
in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell
surface
receptor tyrosine kinases and growth factor receptors. Plays a role in modulating cell spreading and migration.
[a.k.a. XM_024452985, PINCH-2, AF527765]
6)
Homo sapiens
LIMS1 - LIM and senescent cell
antigen
-like-containing domain
protein
1; Adapter
protein
in a cytoplasmic complex linking beta- integrins to the actin cytoskeleton, bridges the complex to cell
surface
receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.
[a.k.a. NP_001358428.1, NM_001193482, CCDS54385]
7)
Homo sapiens
CD209 - CD209
antigen
; Pathogen-recognition receptor expressed on the
surface
of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane
surface
and the pathogen-derived
antigens
are presented to resting T-cells via MHC class II
proteins
to initiate the adaptive immune response. (Microbial infection) Acts as an attachment receptor for HIV- 1 and HIV-2. (Microbial infection) Acts as an attachment receptor for Cytomegal [...]
[a.k.a. ENST00000602261.5, ENST00000593821, CCDS45952]
8)
Homo sapiens
CD8A - T-cell
surface
glycoprotein CD8 alpha chain; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The
antigens
presented by class I peptides are derived from cytosolic
proteins
while class II derived from extracellular
proteins
. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I
proteins
presented by
antigen
presenting cells (APCs). In turn, recruits the Sr [...]
[a.k.a. Q4ZG17, hsa:925, CD8]
9)
Homo sapiens
B2M - Beta-2-microglobulin form pI 5.3; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide
antigens
to the immune system. Exogenously applied M.tuberculosis EsxA or EsxA-EsxB (or EsxA expressed in host) binds B2M and decreases its export to the cell
surface
(total
protein
levels do not change), probably leading to defects in class I
antigen
presentation. Belongs to the beta-2-microglobulin family.
[a.k.a. 4QOK, 1HLA, 1T20]
10)
Homo sapiens
SPAG16 - Sperm-associated
antigen
16
protein
; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical
surface
of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia (By similarity).
[a.k.a. XP_011510122, CAH18307.1, AC079610]
11)
Homo sapiens
LY9 - T-lymphocyte
surface
antigen
Ly-9; Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter
proteins
, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophil [...]
[a.k.a. ENST00000368038, ENST00000325549, hly9]
12)
Homo sapiens
CD9 - CD9
antigen
; Integral membrane
protein
associated with integrins, which regulates different processes, such as sperm-egg fusion, platelet activation and aggregation, and cell adhesion. Present at the cell
surface
of oocytes and plays a key role in sperm-egg fusion, possibly by organizing multiprotein complexes and the morphology of the membrane required for the fusion (By similarity). In myoblasts, associates with CD81 and PTGFRN and inhibits myotube fusion during muscle regeneration (By similarity). In macrophages, associates with CD81 and beta-1 and beta-2 integrins, and prevents mac [...]
[a.k.a. XP_005253871.1, AAA51958.1, uc001qnq.3]
13)
Homo sapiens
TNIP1 - TNFAIP3-interacting
protein
1; Inhibits NF-kappa-B activation and TNF-induced NF-kappa-B- dependent gene expression by regulating A20/TNFAIP3-mediated deubiquitination of IKBKG; proposed to link A20/TNFAIP3 to ubiquitinated IKBKG. Involved in regulation of EGF-induced ERK1/ERK2 signaling pathway; blocks MAPK3/MAPK1 nuclear translocation and MAPK1- dependent transcription. Increases cell
surface
CD4(T4)
antigen
expression. Involved in the anti-inflammatory response of macrophages and positively regulates TLR-induced activation of CEBPB. Involved in the prevention of autoimmunity; this f [...]
[a.k.a. ENSP00000430279, KIAA0113, Q15025]
14)
Homo sapiens
SIRPG - Signal-regulatory
protein
gamma; Probable immunoglobulin-like cell
surface
receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on
antigen
-presenting cells results in enhanced
antigen
- specific T-cell proliferation and costimulates T-cell activation.
[a.k.a. CCDS13020.2, R-HSA-202733, AB042624]
15)
Homo sapiens
HMHB1 - Minor histocompatibility
antigen
HB-1; Precursor of the histocomplatibility
antigen
HB-1. More generally, minor histocomplatibility
antigens
(mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular
proteins
, which are cleaved by normal pathways of
antigen
processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell
surface
can stimulate T-cell responses and thereby trigger graft rejection or graft-ver [...]
[a.k.a. Histocompatibility minor HB-1, AF103884, BC104412]
16)
Homo sapiens
CLEC4C - C-type lectin domain family 4 member C; Lectin-type cell
surface
receptor which may play a role in
antigen
capturing by dendritic cells. Specifically recognizes non-sialylated galactose- terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man. Binds to serum IgG. Efficiently targets ligand into
antigen
-processing and peptide-loading compartments for presentation to T-cells. May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells. May act as a signaling receptor that activates
protein
-tyrosine k [...]
[a.k.a. ENST00000354629, CHEMBL2176855, HECL]
17)
Homo sapiens
LCK - Tyrosine-
protein
kinase Lck; Non-receptor tyrosine-
protein
kinase that plays an essential role in the selection and maturation of developing T-cells in the thymus and in the function of mature T-cells. Plays a key role in T- cell
antigen
receptor (TCR)-linked signal transduction pathways. Constitutively associated with the cytoplasmic portions of the CD4 and CD8
surface
receptors. Association of the TCR with a peptide
antigen
- bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, thereby recruiting the associated LCK
protein
[...]
[a.k.a. 3BRH, M36881, R-HSA-202733]
18)
Homo sapiens
HLA-DRA - HLA class II histocompatibility
antigen
, DR alpha chain; Binds peptides derived from
antigens
that access the endocytic route of
antigen
presenting cells (APC) and presents them on the cell
surface
for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of
proteins
that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous
antigens
that have been endocytosed by the APC are thus readily available for pre [...]
[a.k.a. 1T5W, 3122, 2FSE]
19)
Homo sapiens
HLA-DQA2 - HLA class II histocompatibility
antigen
, DQ alpha 2 chain; Binds peptides derived from
antigens
that access the endocytic route of
antigen
presenting cells (APC) and presents them on the cell
surface
for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of
proteins
that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous
antigens
that have been endocytosed by the APC are thus readily available for p [...]
[a.k.a. HLA-DQA1, KY500360, CAM26196.1]
20)
Homo sapiens
HLA-DQB1 - HLA class II histocompatibility
antigen
, DQ beta 1 chain; Binds peptides derived from
antigens
that access the endocytic route of
antigen
presenting cells (APC) and presents them on the cell
surface
for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of
proteins
that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous
antigens
that have been endocytosed by the APC are thus readily available for pr [...]
[a.k.a. Q30095, ENSP00000308869, UPI000012C0BC]
3671 matches
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